EPSRC Centre for Doctoral Training
نویسنده
چکیده
The overarching aim of the project is to develop a noninvasive biopsy system that can image the molecular signatures of a disease in its in vivo native state, in 3D, and throughout the progression of the disease. A focused ultrasound-based drug delivery system will be used to noninvasively and locally deliver normally impermeable targeted MRI contrast agents across the capillaries of a target disease (such as breast cancer). MRI pulse sequences will then be optimised to detect the bound targeted MRI contrast agents in vivo from the surrounding tissue and unbound contrast agents. The sub-aims of this project are (1) to design ultrasound parameters for delivering targeted MRI contrast agents, (2) to identify and/or design targeted MRI contrast agents that could provide sufficient signal contrast when delivered by ultrasound, and (3) to optimise MRI pulse sequences to identify bound targeted contrast agents.
منابع مشابه
Erratum: The Biosynthesis of Infrared-Emitting Quantum Dots in Allium Fistulosum
“S.J.H. and E.A.L. acknowledge funding from the Engineering and Physical Sciences Research Council (EPSRC) UK Grants EP/G035954/1 and EP/J021172/1 and from the Defence Threat Reduction Agency Grant HDTRA112-1-0013. E.A.L. would like to thank the North West Nanoscience Doctoral Training Centre (NOWNano DTC) for supporting his studentship. The authors wish to acknowledge the support from H.M. Gov...
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